Myers Cooper was born in Licking County, Ohio in 1873. His family had migrated to Ohio from Pennsylvania after the Civil War. Cooper attended the National Normal University in Lebanon, Ohio. In1894, Cooper went into the real estate business with two brothers in Cincinnati, and later expanded the enterprise into the home building portion of the industry. His first attempt at politics was his run for Governor in 1926, however he had been associated closely with the Republican Party in Cincinnati before that time. He had also been a delegate to the Republican conventions since 1916. He barely lost the 1926 election to Victor Donahey, and positioned himself perfectly for the 1928 race in which he was successful. Cooper lost his re-election attempt in 1930 against George White.